Well, an updated version anyhow! And now at http://jvelotta.com. Check out my most up-to-date CV and research highlights
I had the pleasure of speaking at a symposium on the role of phenotypic plasticity in evolution at the Evolution 2018 in Montpellier France recently. My talk on the role of maladaptive plasticity in adaptation to high-altitude can be viewed below. It features new unpublished work from an experiment using 6 species of Peromyscus as well data from my recent papers in Evolution and Integrative and Comparative Biology.
As of April 2017, I’ve been accepted as an NIH postdoctoral fellow at the University of Montana! My project will explore the physiological and fitness consequences of selection on Epas1, a master regulator of the body’s response to hypoxia. This gene is under strong natural selection in highland populations of deer mice, as well as humans, wolves, and many other mammals native to high-elevations.
Here is how this project is relevant to the NIHs goals:
The disruption of oxygen homeostasis is a crucial feature in the pathophysiology of many common and devastating diseases, including heart disease, chronic lung disease, and cerebrovascular disease. Populations (e.g., highland Tibetan humans) that have adapted to high-altitude environments are protected from the negative effects of extremely low oxygen availability (hypoxia), in part because they have modified a key hypoxia-signaling pathway known as the hypoxia-inducible factor (HIF) cascade. I propose to use deer mice (Peromyscus maniculatus), which have naturally adapted to high-altitude, as a model to determine the molecular and genetic mechanisms by which heart, lung, and blood responses to hypoxia benefit from Darwinian selection on the HIF cascade. A mechanistic understanding of adaptation to hypoxia will yield insight into novel therapies in the treatment of diseases related to the loss of oxygen homeostasis.
Team deer mouse just finished up a successful field season at Mt. Evans CO testing for the effects of variation in the epas1 gene on metabolic performance and breathing under hypoxia. Check the Projects tab soon for more exciting details!
New publication exploring the evolution of non-shivering thermogenesis in high-altitude mice. http://onlinelibrary.wiley.com/doi/10.1111/mec.13661/full
The Cheviron Lab has moved to the University of Montana, and so have I! It’s been real Illinois!
I’m very excited to be starting a new postdoc in the Cheviron Lab at the University of Illinois, where I’ll be joining a team studying the systems biology and evolution of thermoregulatory performance in high-altitude deer mice.